Endocrine Abstracts

Introduction: Hypophysitis is a rare association of inflammatory bowel disease (IBD) with only few cases reported in the literature. It can present with isolated hormone deficiencies or panhypopituitarism. Patients may also present with symptoms secondary to inflammatory pituitary mass. Management consists of hormone replacement therapy, but high dose steroids, steroid sparing agents like Rituximab or even surgery may be required for mass effect.Case rep...

Background: Immobility can be associated with severe hypercalcaemia, especially when compounded by other risk factors such as concurrent hyperthyroidism and high dietary calcium/milk intake and associated complications such as renal stones and fractures.Clinical case: 59y female presented acutely with confusion, vomiting, constipation and muscle weakness. She had history of obesity, stable Crohn’s disease with no recent increase in colonostomy outpu...

35y woman presented to haematology with normocytic anaemia and extreme fatigue. Had borderline vitamin B12, but im hydroxocobalamin did not improve Hb. A trial of iv iron was also ineffective. Bone marrow biopsy showed hypocellular bone marrow with suppressed erythropoiesis. In the absence of underlying cause, commenced prednisolone with significant improvement in Hb from 117 to 134 g/l and she felt better. Prednisolone was continued at 5 mg od. Fatigue, musculoskeletal sympto...

35y woman presented to haematology with normocytic anaemia and extreme fatigue. Had borderline vitamin B12, but im hydroxocobalamin did not improve Hb. A trial of iv iron was also ineffective. Bone marrow biopsy showed hypocellular bone marrow with suppressed erythropoiesis. In the absence of underlying cause, commenced prednisolone with significant improvement in Hb from 117 to 134 g/l and she felt better. Prednisolone was continued at 5 mg od. Fatigue, musculoskeletal sympto...

Background: Langerhans cell histiocytosis (LCH) is an uncommon myeloproliferative disorder characterised by inflammatory lesions and accumulation of histiocytes leading to the destruction of affected tissues. LCH has a variable presentation and can occur as a single indolent lesion or can affect multiple organs such as the pituitary gland, bones, CNS, liver, lungs, lymph nodes, spleen, skin, heart and gastrointestinal tract. LCH of the pituitary gland most com...

18 year old student was referred by the Gynaecology team with primary amenorrhoea, delayed puberty, and minimum breast development. History: The patient was born by an emergency caesarean section with a birth weight of eight pounds and four ounces. She had a normal development during infancy and childhood and there was no reported developmental delay in the family. She had adrenarche at the age of ten with a normal appearance of axillary and pubic hair....

17 year old male was referred by GP with short stature and delayed development of secondary sex characteristics. History: He was born at full term with a bodyweight of eight pounds and normal development till adolescence. He is the second out of three children and as his parents and siblings entered puberty at expected ages and he has not suffered from the chronic illness make constitutional delay of puberty or functional hypothalamic hypogonadism less l...

Lymphoma can cause adrenal glands infiltration, but only a handful of cases of adrenal involvement have been reported in classical Hodgkin’s lymphoma. We present a case of 24y male of Indian origin presenting with B symptoms, AKI, breathlessness, and diarrhoea. CT CAP showed lymphadenopathy, enlarged kidneys and adrenal glands bilaterally. 18F-FDG PET CT showed PET avid lymphadenopathy and non-avid bilateral adrenal masses. Histology of axillary lymph node conf...

We present a case of 70 year-old-man, who was referred to the endocrine clinic with incidentally detected 26 mm lesion arising from the left adrenal gland suspicious of pheochromocytoma. This was detected during investigations for asymptomatic microscopic haematuria. He did not describe the typical symptoms of pheochromocytoma (episodic headaches, sweating, tachycardia), but interestingly 4–5 months previously was diagnosed with an acute onset of psychosis with paranoid d...

Hyperparathyroidism is rarely encountered in pregnancy; however, the consequence of untreated disease can be significant for both the mother and fetus (increased risk of miscarriage, IUGR, pre-eclampsia, neonatal hypocalcaemia). NICE guidance (May 2019) on the management of PHPT strongly recommends disease control pre-pregnancy, MDT working and offering surgery if cCa is above 2.85 mmol/l. We report a 31-year-old P4 who was referred to our joint endocrine/obstetric clinic at 1...